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My name is Tatiana Klyakovkina. My sister Anya has aplastic anemia.
This disease was diagnosed in Yoshkar-Ola, the capital of our republic
Mari El in the Volga region.
We spent three months at the local hospital, and then Anya was
sent to the Russian Children's Clinical Hospital in Moscow for marrow
transplantation. The transplantation took place on June 22, 2006, but
it was not enough, because the amount of donor cells produced by
the marrow is smaller than the amount of her own cells. Considering this
situation, the second transplantation of stem cells was recommended.
But, in addition, radiation therapy has been prescribed. We need money
for this treatment, but, unfortunately, we have none.
Our mother receives only a small old-age pension. Our father is disabled.
We have three more children in our family, and all of them still
go to school.
Our only source of income was my job. But I had to quit it to accompany
my sister to the hospital and take constant care of her here. There is
nobody else to help her, and we are alone with our grief. Your support
can help our Anya recover and have a normal life again. Before her
illness, she studied to become a vet. This is still her dream. But
now she just hopes and believes that somebody will help her.
Thank you very much!
Tatiana and Anna Klyakovkins
The doctor's comment
Anna Klyakovkina has been a patient of the Marrow Transplantation
Department since June 6, 2006. Her diagnosis is severe form of
aplastic anemia. She underwent allogeneic marrow transplantation
from an HLA-identical donor on June 22, 2006. After it, she had acute
graft vs. host disease, stage 2. Cytomegalovirus infection. Considering
the main diagnosis and the large number of transfusions prior to
the transplantation, high risk of graft rejection was expected.
Presently the girl is in grave condition owing to aplasia of
hematopoiesis accompanied by graft rejection. She depends on everyday
transfusions. In this situation, repeated transplantation of hematopoietic
stem cells is urgently necessary. Also, the girl in this condition
needs many drugs that are currently lacking at the hospital.
Head of the Department of Marrow Transplantation, RCCH
Elena V. Skorobogatova
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News
10.05.2007 This night, Anya
Klyakovkina died. She had a very kind and pure soul. In spite of repeated
transplantations of donor cells, she did not respond to treatment.
The physicians fought for her life to the last moment. It is very painful
to think that she is no longer with us.
22.04.2007 Information from E.V. Skorobogatova:
"Anya Klyakovkina felt worse again during the last week. Graft hypofunction
has become more marked. The WBC count has decreased. She receives
frequent transfusions. Multiorgan and respiratory insufficiency
are progressing (Anya needs oxygen supply), as well as cardiac and renal
insufficiency. Viral problems are also present. We are
performing all the necessary therapy, but, unfortunately, the girl's
immunity is impaired, because she has been in aplasia of hematopoiesis
since June. Certainly, we will struggle, but there is nothing more
to say as yet."
4.04.2007
E.V. Skorobogatova, Department of Marrow Transplantation:
"Anya Klyakovkina has had
her fourth transplantation for graft hypofunctioning. And this time
it was successful. Now the girl's main problem is CMV infection,
because this infection itself and its treatment reduce the blood
counts. The girl needs transfusions again. However, she has no
fever. There was an exacerbation of the graft vs. host disease
involving her skin and intestines, but Anya responded well
to hormonal treatment."
16.03.2007
Dr. Elena V. Skorobogatova, Head of the Department of Marrow Transplantation:
"Anya Klyakovkina has
already undergone three transplantations for acquired aplastic anemia.
There were two graft rejections, and only now, a month after the
third transplantation, restoration of leukopoiesis is observed.
However, the girl still needs frequent transfusions of blood components.
Her infectious status is comparatively fine. Next Monday, we will
perform an exclusive procedure: intraosseous introduction of
stromal cells grown over seven weeks. These cells
represent the microenvironment of blood cells in the bone marrow.
And we will also infused her brother's marrow (it will be her
fourth transplantation!), with part of this marrow being administered
into the bone as well. This is necessary for restoration of
thrombocytopoiesis and erythropoiesis. We have already performed
only one intraosseous transplantation for a patient with
similar problems, and it was highly successful."
21.02.2007
Elena V. Skorobogatova, Head of the Department of Marrow Transplantation, tells:
"Anya Klyakovkina had her third
transplantation two weeks ago. During the last two days, her WBC count
rose to 1000. Before that, for the last three months, this count was
from 0.1 to 0.3, and so we hope that this time engraftment will
take place. And she is in better spirits."
18.02.2007 Elena V. Skorobogatova, Head of the Department
of Marrow Transplantation, tells:
"Last week, Anya Klyakovkina
had her third transplantation from the same donor. There are no signs
of engraftment as yet, but the girl has no high fever now, and she
is in somewhat better spirits. There is no evidence for acute or
chronic graft vs. host disease."
16.01.2007
Almost two months have passed since Anya
Klyakovkina had her transplantation of hematopoietic cells. The graft is
not functioning, although Anya's bone marrow contains cells of donor origin.
Possibly the third transplantation will be performed. Anya is in grave
condition. She has cytomegalovirus infection and complains of
nausea, vomiting, and poor appetite.
29.11.2006 Head of the Department of Marrow Transplantation
Dr. Elena V. Skorobogatova tells about
Anya Klyakovkina:
"On November 21, we performed the second transplantation from Anya's
brother. Prior to it, she received radiation therapy at the Institute
of Roentgenology and Radiology. She is in normal condition and has no
fever. But it is too early to speak of any result. We can assess
the engraftment only in three or four weeks."
They have helped
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